The Office for the Impact Economy is offering £1.5 million for redesigned health and care services.
The projects will help patients receive joined-up support earlier, avoid unnecessary hospital admissions and remain independent for longer.
Six sites will develop and test new neighbourhood health models that bring together NHS services, councils, community organisations and local people to improve outcomes, tackle inequalities.
The funding will help sites develop and test new neighbourhood health models, which could then be scaled across the country.
The government has partnered with Social Finance, Macmillan Cancer Support and West Hertfordshire Teaching Hospitals NHS Trust to bring together expertise in cancer care, system transformation, innovative finance and neighbourhood health.
Bristol NHS Foundation Trust will run a 1,000 Days Neighbourhood Model that uses population health data and community networks to improve end-of-life care and support more people with frailty and multiple conditions outside hospital settings.
Lewisham Health and Care Partnership and Healthier Greenwich Partnership will launch an integrated neighbourhood model covering long-term conditions, frailty, cancer and end of life care, building on existing Integrated Neighbourhood Teams while making cancer a more explicit focus.
Dame Diana Johnson Minister of State for Health said: "Neighbourhood health is about bringing services together within our local communities, helping people get the right care, at the right time, closer to home.
"These six trailblazer pilots will help lead the way in showing how locally-led services can work together in the areas of greatest need, and support people to live healthier, more independent lives.
"The programme is a key part of our 10 Year Health Plan, helping us shift from treating sickness to preventing it in the first place, and giving people the help they need in the heart of their own communities."
Minister of State Stephanie Peacock said: "These six trailblazers show how government, local services, communities and impact investors, working together, can rewire the state to build a healthier nation and stronger local economies."
